GxPlex

Observation series — EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity

← DI revision concept paper

156 observation(s) recorded. 156 carry an address; none is without one. 155 retained normalised text and hold a digest. 1 hold none: 1 where no response arrived; and none was hashed.

Each observation is addressed by this row’s identifier, the date it was observed, and its sequence within that date — the same key /api/v1/series.jsonl publishes as `sequence`, counted in the order the store recorded them.

This digest is a leaf of the integrity root, and the command that recomputes it is published at /verify/.

Every addressed record below carries its own citation, naming the day, the URL that answered, the response as recorded, and the digest where one exists. Where none exists the citation says so and asserts no digest.

The GXP-OBS statements on the field a column renders: Normalised textcontent_length · The document observation · GXP-OBS version 1What it records Characters of normalised content.What it does not claim It measures the normalisation, not the document, and it is not a measure of how much a document says.Absent or null means Written as 0 wherever no digest was taken. A 0 here is the absence of a measurement and never a measured empty document.In the glossary · GXP-OBS
Address Date Outcome Method Normalised text SHA-256 of normalised text
2026-07-31·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-07-31·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-07-31 (record 1 of that day)
Requested:   https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice
             (no answering URL was recorded for this observation)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-07-31-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-07-31·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-07-31·2
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-07-31·2
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-07-31 (record 2 of that day)
Requested:   https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice
             (no answering URL was recorded for this observation)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31 — the day this
             observation was recorded, UTC.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-07-31-2
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-07-31·2; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-07-31·3
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-07-31·3
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-07-31 (record 3 of that day)
Requested:   https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice
             (no answering URL was recorded for this observation)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31 — the day this
             observation was recorded, UTC.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-07-31-3
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-07-31·3; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-07-31·4
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-07-31·4
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-07-31 (record 4 of that day)
Requested:   https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice
             (no answering URL was recorded for this observation)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31 — the day this
             observation was recorded, UTC.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-07-31-4
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-07-31·4; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-07-31·5
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-07-31·5
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-07-31 (record 5 of that day)
Requested:   https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice
             (no answering URL was recorded for this observation)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31 — the day this
             observation was recorded, UTC.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-07-31-5
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-07-31·5; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-01·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-01·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-01 (record 1 of that day)
Requested:   https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice
             (no answering URL was recorded for this observation)
Response:    HTTP 200, fetched direct, 92,532 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-01 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-01-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-01·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,532 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-01·2
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-01·2
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-01 (record 2 of that day)
Requested:   https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice
             (no answering URL was recorded for this observation)
Response:    HTTP 200, fetched direct, 92,532 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-01 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-01-2
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-01·2; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,532 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-01·3
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-01·3
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-01 (record 3 of that day)
Requested:   https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice
             (no answering URL was recorded for this observation)
Response:    HTTP 200, fetched direct, 92,531 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-02 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-01-3
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-01·3; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,531 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-02·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-02·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-02 (record 1 of that day)
Requested:   https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice
             (no answering URL was recorded for this observation)
Response:    HTTP 200, fetched direct, 92,531 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-02 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-02-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-02·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,531 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-02·2
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-02·2
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-02 (record 2 of that day)
Requested:   https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice
             (no answering URL was recorded for this observation)
Response:    HTTP 200, fetched direct, 92,531 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-02 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-02-2
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-02·2; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,531 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-02·3
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-02·3
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-02 (record 3 of that day)
Requested:   https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice
             (no answering URL was recorded for this observation)
Response:    HTTP 200, fetched direct, 92,531 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-02 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-02-3
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-02·3; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,531 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-03·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-03·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-03 (record 1 of that day)
Requested:   https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice
             (no answering URL was recorded for this observation)
Response:    HTTP 200, fetched direct, 92,534 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-03 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-03-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-03·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,534 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-03·2
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-03·2
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-03 (record 2 of that day)
Requested:   https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice
             (no answering URL was recorded for this observation)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-03 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-03-2
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-03·2; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-03·3
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-03·3
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-03 (record 3 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-03 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-03-3
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-03·3; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-04·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-04·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-04 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-04 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-04-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-04·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-04·2
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-04·2
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-04 (record 2 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,534 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-04 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-04-2
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-04·2; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,534 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-05·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-05·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-05 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,534 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-05 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-05-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-05·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,534 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-05·2
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-05·2
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-05 (record 2 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,534 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-05 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-05-2
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-05·2; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,534 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-05·3
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-05·3
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-05 (record 3 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,534 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-05 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-05-3
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-05·3; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,534 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-06·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-06·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-06 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,534 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-06 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-06-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-06·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,534 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-06·2
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-06·2
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-06 (record 2 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,534 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-06 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-06-2
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-06·2; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,534 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-07·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-07·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-07 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,534 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-07 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-07-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-07·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,534 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-08·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-08·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-08 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,534 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-08 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-08-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-08·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,534 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-08·2
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-08·2
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-08 (record 2 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-08 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-08-2
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-08·2; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-08·3
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-08·3
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-08 (record 3 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-08 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-08-3
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-08·3; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-08·4
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-08·4
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-08 (record 4 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-08 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-08-4
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-08·4; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-09·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-09·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-09 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-09 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-09-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-09·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-09·2
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-09·2
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-09 (record 2 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-09 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-09-2
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-09·2; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-09·3
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-09·3
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-09 (record 3 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-09 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-09-3
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-09·3; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-09·4
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-09·4
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-09 (record 4 of that day)
Requested:   https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice
             (no answering URL was recorded for this observation)
Response:    NO RESPONSE ARRIVED, fetched blocked, URLError
             The collector records a status of 0 and 0 bytes when no response
             arrived; neither is a measurement, and neither is published as
             one.
Digest:      NONE RECORDED. No response arrived, and no normalised text was
             retained for this observation, so nothing was hashed. This
             citation asserts no digest.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-09 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-09-4
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-09·4; the bundle states what
             its proofs cover and its signature state)
 no response arrived · URLError blocked — no response arrived on this occasion, so nothing was hashed
2026-08-09·5
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-09·5
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-09 (record 5 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-09 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-09-5
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-09·5; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-09·6
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-09·6
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-09 (record 6 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-09 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-09-6
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-09·6; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-09·7
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-09·7
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-09 (record 7 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-09 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-09-7
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-09·7; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-09·8
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-09·8
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-09 (record 8 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-09 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-09-8
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-09·8; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-10·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-10·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-10 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,532 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-10 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-10-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-10·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,532 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-10·2
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-10·2
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-10 (record 2 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-10 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-10-2
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-10·2; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-10·3
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-10·3
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-10 (record 3 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-10 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-10-3
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-10·3; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-10·4
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-10·4
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-10 (record 4 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-10 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-10-4
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-10·4; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-10·5
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-10·5
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-10 (record 5 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-10 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-10-5
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-10·5; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-10·6
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-10·6
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-10 (record 6 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-11 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-10-6
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-10·6; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-11·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-11·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-11 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-11 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-11-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-11·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-11·2
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-11·2
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-11 (record 2 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-12 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-11-2
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-11·2; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-11·3
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-11·3
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-11 (record 3 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-12 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-11-3
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-11·3; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-12·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-12·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-12 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-12 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-12-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-12·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-12·2
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-12·2
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-12 (record 2 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-12 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-12-2
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-12·2; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-12·3
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-12·3
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-12 (record 3 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-12 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-12-3
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-12·3; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-12·4
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-12·4
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-12 (record 4 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-12 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-12-4
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-12·4; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-12·5
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-12·5
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-12 (record 5 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-12 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-12-5
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-12·5; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-12·6
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-12·6
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-12 (record 6 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-12 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-12-6
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-12·6; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-12·7
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-12·7
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-12 (record 7 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-12 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-12-7
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-12·7; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-12·8
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-12·8
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-12 (record 8 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-12 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-12-8
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-12·8; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-12·9
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-12·9
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-12 (record 9 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-12 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-12-9
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-12·9; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-13·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-13·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-13 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,534 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-13 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-13-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-13·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,534 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-14·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-14·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-14 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,532 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-14 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-14-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-14·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,532 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-15·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-15·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-15 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,534 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-15 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-15-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-15·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,534 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-15·2
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-15·2
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-15 (record 2 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,534 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-15 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-15-2
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-15·2; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,534 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-15·3
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-15·3
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-15 (record 3 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,534 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-15 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-15-3
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-15·3; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,534 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-16·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-16·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-16 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-16 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-16-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-16·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-16·2
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-16·2
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-16 (record 2 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-16 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-16-2
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-16·2; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-16·3
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-16·3
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-16 (record 3 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-16 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-16-3
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-16·3; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-16·4
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-16·4
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-16 (record 4 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-16 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-16-4
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-16·4; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-17·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-17·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-17 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,532 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-17 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-17-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-17·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,532 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-18·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-18·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-18 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,534 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-18 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-18-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-18·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,534 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-19·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-19·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-19 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-19 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-19-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-19·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-20·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-20·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-20 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-20 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-20-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-20·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-21·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-21·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-21 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-21 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-21-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-21·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-22·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-22·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-22 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,530 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-22 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-22-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-22·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,530 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-22·2
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-22·2
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-22 (record 2 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,530 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-22 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-22-2
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-22·2; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,530 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-23·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-23·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-23 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,536 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-23 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-23-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-23·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,536 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-24·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-24·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-24 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,532 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-24 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-24-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-24·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,532 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-25·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-25·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-25 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,614 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-25 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-25-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-25·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,614 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-25·2
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-25·2
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-25 (record 2 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,747 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-25 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-25-2
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-25·2; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,747 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-26·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-26·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-26 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,616 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-26 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-26-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-26·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,616 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-26·2
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-26·2
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-26 (record 2 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,614 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-26 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-26-2
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-26·2; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,614 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-27·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-27·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-27 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,614 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-27 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-27-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-27·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,614 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-28·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-28·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-28 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,400 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-28 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-28-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-28·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,400 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-29·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-29·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-29 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,402 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-29 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-29-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-29·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,402 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-29·2
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-29·2
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-29 (record 2 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,402 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-29 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-29-2
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-29·2; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,402 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-30·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-30·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-30 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,402 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-30 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-30-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-30·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,402 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-30·2
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-30·2
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-30 (record 2 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,402 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-30 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-30-2
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-30·2; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,402 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-08-31·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-08-31·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-08-31 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,402 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-31 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-08-31-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-08-31·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,402 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-09-01·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-09-01·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-09-01 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,402 bytes returned
Digest:      SHA-256 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-09-01 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-09-01-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-09-01·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,402 bytes returned direct 11,105 chars 208b17ec5cbe3dec1e28bfe934cbc4ff156555c20195553caf8f086f888783f0
2026-09-02·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-09-02·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-09-02 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,402 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-09-02 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-09-02-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-09-02·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,402 bytes returned · digest differed direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-09-02·2
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-09-02·2
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-09-02 (record 2 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,402 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-09-02 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-09-02-2
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-09-02·2; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,402 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-09-03·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-09-03·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-09-03 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,402 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-09-03 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-09-03-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-09-03·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,402 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-09-04·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-09-04·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-09-04 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,399 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-09-04 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-09-04-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-09-04·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,399 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-09-04·2
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-09-04·2
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-09-04 (record 2 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,381 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-09-04 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-09-04-2
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-09-04·2; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,381 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-09-05·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-09-05·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-09-05 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,381 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-09-05 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-09-05-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-09-05·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,381 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-09-05·2
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-09-05·2
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-09-05 (record 2 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,381 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260731131827/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-09-05 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-09-05-2
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-09-05·2; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,381 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-09-05·3
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-09-05·3
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-09-05 (record 3 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,381 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05 — the day this
             observation was recorded, UTC.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-09-05-3
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-09-05·3; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,381 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-09-05·4
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-09-05·4
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-09-05 (record 4 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,381 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05 — the day this
             observation was recorded, UTC.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-09-05-4
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-09-05·4; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,381 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-09-05·5
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-09-05·5
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-09-05 (record 5 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,381 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05 — the day this
             observation was recorded, UTC.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-09-05-5
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-09-05·5; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,381 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-09-05·6
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-09-05·6
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-09-05 (record 6 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,381 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05 — the day this
             observation was recorded, UTC.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-09-05-6
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-09-05·6; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,381 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-09-05·7
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-09-05·7
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-09-05 (record 7 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,381 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05 — the day this
             observation was recorded, UTC.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-09-05-7
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-09-05·7; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,381 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-09-05·8
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-09-05·8
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-09-05 (record 8 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,381 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05 — the day this
             observation was recorded, UTC.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-09-05-8
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-09-05·8; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,381 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-09-05·9
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-09-05·9
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-09-05 (record 9 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,381 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05 — the day this
             observation was recorded, UTC.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-09-05-9
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-09-05·9; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,381 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-09-06·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-09-06·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-09-06 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,381 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-09-06 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-09-06-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-09-06·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,381 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-09-07·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-09-07·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-09-07 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,383 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-09-07 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-09-07-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-09-07·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,383 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-09-08·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-09-08·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-09-08 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,377 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-09-08 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-09-08-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-09-08·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,377 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-09-09·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-09-09·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-09-09 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,379 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-09-09 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-09-09-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-09-09·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,379 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-09-10·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-09-10·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-09-10 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,381 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-09-10 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-09-10-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-09-10·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,381 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-09-11·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-09-11·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-09-11 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,595 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-09-11 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-09-11-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-09-11·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,595 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-09-12·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-09-12·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-09-12 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,589 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-09-12 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-09-12-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-09-12·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,589 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-09-13·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-09-13·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-09-13 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,595 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-09-13 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-09-13-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-09-13·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,595 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-09-14·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-09-14·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-09-14 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,593 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-09-14 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-09-14-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-09-14·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,593 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-09-15·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-09-15·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-09-15 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,577 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-09-15 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-09-15-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-09-15·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,577 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-09-16·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-09-16·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-09-16 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,579 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-09-16 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-09-16-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-09-16·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,579 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-09-17·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-09-17·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-09-17 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,579 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-09-17 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-09-17-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-09-17·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,579 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-09-18·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-09-18·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-09-18 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,579 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-09-18 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-09-18-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-09-18·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,579 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-09-19·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-09-19·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-09-19 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,575 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-09-19 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-09-19-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-09-19·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,575 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-09-20·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-09-20·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-09-20 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,575 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-09-20 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-09-20-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-09-20·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,575 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-09-21·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-09-21·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-09-21 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,575 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-09-21 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-09-21-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-09-21·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,575 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-09-22·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-09-22·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-09-22 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,571 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-09-22 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-09-22-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-09-22·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,571 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-09-23·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-09-23·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-09-23 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,574 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-09-23 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-09-23-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-09-23·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,574 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-09-24·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-09-24·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-09-24 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,575 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-09-24 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-09-24-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-09-24·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,575 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-09-25·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-09-25·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-09-25 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,687 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-09-25 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-09-25-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-09-25·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,687 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-09-26·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-09-26·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-09-26 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,811 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-09-26 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-09-26-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-09-26·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,811 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-09-27·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-09-27·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-09-27 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,811 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-09-27 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-09-27-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-09-27·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,811 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-09-28·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-09-28·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-09-28 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 92,815 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-09-28 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-09-28-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-09-28·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 92,815 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-09-29·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-09-29·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-09-29 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,557 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-09-29 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-09-29-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-09-29·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,557 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-09-30·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-09-30·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-09-30 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,563 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-09-30 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-09-30-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-09-30·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,563 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-10-01·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-10-01·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-10-01 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,563 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-10-01 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-10-01-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-10-01·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,563 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-10-01·2
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-10-01·2
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-10-01 (record 2 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,563 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-10-01 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-10-01-2
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-10-01·2; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,563 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-10-02·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-10-02·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-10-02 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,563 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-10-02 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-10-02-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-10-02·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,563 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-10-03·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-10-03·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-10-03 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,561 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-10-03 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-10-03-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-10-03·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,561 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-10-04·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-10-04·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-10-04 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,561 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-10-04 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-10-04-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-10-04·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,561 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-10-05·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-10-05·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-10-05 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,561 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-10-05 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-10-05-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-10-05·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,561 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-10-06·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-10-06·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-10-06 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,560 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-10-06 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-10-06-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-10-06·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,560 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-10-07·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-10-07·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-10-07 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,563 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-10-07 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-10-07-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-10-07·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,563 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-10-08·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-10-08·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-10-08 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,561 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-10-08 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-10-08-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-10-08·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,561 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-10-09·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-10-09·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-10-09 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,561 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-10-09 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-10-09-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-10-09·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,561 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-10-10·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-10-10·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-10-10 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,561 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-10-10 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-10-10-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-10-10·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,561 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-10-11·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-10-11·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-10-11 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,561 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-10-11 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-10-11-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-10-11·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,561 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-10-11·2
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-10-11·2
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-10-11 (record 2 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,561 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-10-11 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-10-11-2
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-10-11·2; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,561 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-10-12·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-10-12·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-10-12 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,561 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-10-12 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-10-12-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-10-12·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,561 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-10-13·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-10-13·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-10-13 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,563 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-10-13 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-10-13-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-10-13·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,563 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-10-14·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-10-14·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-10-14 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,555 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-10-14 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-10-14-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-10-14·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,555 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-10-15·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-10-15·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-10-15 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,339 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-10-15 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-10-15-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-10-15·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,339 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-10-16·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-10-16·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-10-16 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,337 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-10-16 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-10-16-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-10-16·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,337 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-10-17·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-10-17·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-10-17 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,337 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-10-17 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-10-17-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-10-17·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,337 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-10-18·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-10-18·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-10-18 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,337 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-10-18 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-10-18-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-10-18·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,337 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-10-19·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-10-19·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-10-19 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,339 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20260905102209/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-09-05, before this observation
             was recorded on 2026-10-19 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-10-19-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-10-19·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,339 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-10-20·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-10-20·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-10-20 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,339 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20261020080022/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-10-20 — the day this
             observation was recorded, UTC.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-10-20-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-10-20·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,339 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-10-21·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-10-21·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-10-21 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,337 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20261020080022/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-10-20, before this observation
             was recorded on 2026-10-21 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-10-21-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-10-21·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,337 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-10-22·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-10-22·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-10-22 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,335 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20261020080022/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-10-20, before this observation
             was recorded on 2026-10-22 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-10-22-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-10-22·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,335 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-10-23·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-10-23·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-10-23 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,339 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20261020080022/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-10-20, before this observation
             was recorded on 2026-10-23 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-10-23-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-10-23·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,339 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-10-24·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-10-24·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-10-24 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,339 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20261020080022/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-10-20, before this observation
             was recorded on 2026-10-24 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-10-24-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-10-24·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,339 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-10-25·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-10-25·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-10-25 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,335 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20261020080022/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-10-20, before this observation
             was recorded on 2026-10-25 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-10-25-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-10-25·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,335 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-10-26·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-10-26·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-10-26 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,339 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20261020080022/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-10-20, before this observation
             was recorded on 2026-10-26 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-10-26-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-10-26·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,339 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-10-27·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-10-27·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-10-27 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,440 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20261020080022/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-10-20, before this observation
             was recorded on 2026-10-27 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-10-27-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-10-27·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,440 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-10-28·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-10-28·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-10-28 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,440 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20261020080022/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-10-20, before this observation
             was recorded on 2026-10-28 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-10-28-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-10-28·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,440 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-10-29·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-10-29·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-10-29 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,440 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20261020080022/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-10-20, before this observation
             was recorded on 2026-10-29 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-10-29-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-10-29·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,440 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-10-30·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-10-30·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-10-30 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,438 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20261020080022/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-10-20, before this observation
             was recorded on 2026-10-30 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-10-30-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-10-30·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,438 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-10-31·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-10-31·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-10-31 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,438 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20261020080022/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-10-20, before this observation
             was recorded on 2026-10-31 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-10-31-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-10-31·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,438 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-11-01·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-11-01·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-11-01 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,438 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20261020080022/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-10-20, before this observation
             was recorded on 2026-11-01 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-11-01-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-11-01·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,438 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
2026-11-02·1
Cite this observation 
GxPlex observation record ema-pics-data-integrity-concept 2026-11-02·1
Document:    EMA and PIC/S concept paper on the revision of GMP guidance on data management and integrity
Observed:    2026-11-02 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (requested https://www.ema.europa.eu/en/human-regulatory-overview/research-and-development/compliance-research-and-development/good-manufacturing-practice; the publisher redirected)
Response:    HTTP 200, fetched direct, 93,438 bytes returned
Digest:      SHA-256 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900
             11,105 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/how/; the command
             that recomputes a digest is published at
             https://gxplex.com/verify/.
Capture:     https://web.archive.org/web/20261020080022/https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
             (Internet Archive, submitted 2026-10-20, before this observation
             was recorded on 2026-11-02 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-data-integrity-concept#obs-2026-11-02-1
Full record: https://gxplex.com/api/v1/series.jsonl
Bundle:      https://gxplex.com/api/v1/observation-bundle/ema-pics-data-integrity-concept.json
             (this observation under key 2026-11-02·1; the bundle states what
             its proofs cover and its signature state)
 HTTP 200 · 93,438 bytes returned direct 11,105 chars 4f4cdfc131434b72b1d97db1d28d127af2ef84fa7f794880f88216d2ca179900

Every record above is published untruncated at /api/v1/series.jsonl, which carries the same sequence these addresses are built from.