GxPlex

Observation series — EMA and PIC/S concept paper on the revision of GMP Annex 15

← Annex 15 revision concept paper

109 observation(s) recorded. 109 carry an address; none is without one. 105 retained normalised text and hold a digest. 4 hold none: 1 where no response arrived; 3 where a server answered and no response body was recorded; and none was hashed.

Each observation is addressed by this row’s identifier, the date it was observed, and its sequence within that date — the same key /api/v1/series.jsonl publishes as `sequence`, counted in the order the store recorded them.

This digest is a leaf of the integrity root, and the command that recomputes it is published at /verify.

Every addressed record below carries its own citation, naming the day, the URL that answered, the response as recorded, and the digest where one exists. Where none exists the citation says so and asserts no digest.

Address Date Outcome Method Normalised text SHA-256 of normalised text
2026-07-31·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-07-31·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-07-31 (record 1 of that day)
Requested:   https://health.ec.europa.eu/medicinal-products/eudralex/eudralex-volume-4/consultation-documents_en?annex15
             (no answering URL was recorded for this observation)
Response:    HTTP 404, fetched blocked, no response body was recorded
Digest:      NONE RECORDED. No response body was recorded, and no normalised
             text was retained for this observation, so nothing was hashed.
             This citation asserts no digest.
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-07-31-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 404 · no response body recorded · HTTP 404 blocked — a server answered and no response body was recorded, so nothing was hashed
2026-07-31·2
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-07-31·2
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-07-31 (record 2 of that day)
Requested:   https://health.ec.europa.eu/medicinal-products/eudralex/eudralex-volume-4/consultation-documents_en?annex15
             (no answering URL was recorded for this observation)
Response:    HTTP 404, fetched blocked, no response body was recorded
Digest:      NONE RECORDED. No response body was recorded, and no normalised
             text was retained for this observation, so nothing was hashed.
             This citation asserts no digest.
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-07-31-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 404 · no response body recorded · HTTP 404 blocked — a server answered and no response body was recorded, so nothing was hashed
2026-07-31·3
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-07-31·3
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-07-31 (record 3 of that day)
Requested:   https://health.ec.europa.eu/medicinal-products/eudralex/eudralex-volume-4/consultation-documents_en?annex15
             (no answering URL was recorded for this observation)
Response:    HTTP 404, fetched blocked, no response body was recorded
Digest:      NONE RECORDED. No response body was recorded, and no normalised
             text was retained for this observation, so nothing was hashed.
             This citation asserts no digest.
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-07-31-3
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 404 · no response body recorded · HTTP 404 blocked — a server answered and no response body was recorded, so nothing was hashed
2026-07-31·4
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-07-31·4
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-07-31 (record 4 of that day)
Requested:   https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (no answering URL was recorded for this observation)
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31 — the day this
             observation was recorded, UTC.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-07-31-4
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-07-31·5
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-07-31·5
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-07-31 (record 5 of that day)
Requested:   https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (no answering URL was recorded for this observation)
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31 — the day this
             observation was recorded, UTC.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-07-31-5
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-01·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-01·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-01 (record 1 of that day)
Requested:   https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (no answering URL was recorded for this observation)
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-01 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-01-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-01·2
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-01·2
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-01 (record 2 of that day)
Requested:   https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (no answering URL was recorded for this observation)
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-01 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-01-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-01·3
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-01·3
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-01 (record 3 of that day)
Requested:   https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (no answering URL was recorded for this observation)
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-02 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-01-3
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-02·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-02·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-02 (record 1 of that day)
Requested:   https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (no answering URL was recorded for this observation)
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-02 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-02-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-02·2
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-02·2
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-02 (record 2 of that day)
Requested:   https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (no answering URL was recorded for this observation)
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-02 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-02-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-02·3
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-02·3
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-02 (record 3 of that day)
Requested:   https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (no answering URL was recorded for this observation)
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-02 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-02-3
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-03·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-03·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-03 (record 1 of that day)
Requested:   https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (no answering URL was recorded for this observation)
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-03 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-03-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-03·2
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-03·2
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-03 (record 2 of that day)
Requested:   https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (no answering URL was recorded for this observation)
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-03 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-03-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-03·3
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-03·3
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-03 (record 3 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-03 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-03-3
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-04·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-04·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-04 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-04 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-04-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-04·2
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-04·2
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-04 (record 2 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-04 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-04-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-05·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-05·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-05 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-05 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-05-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-05·2
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-05·2
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-05 (record 2 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-05 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-05-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-05·3
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-05·3
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-05 (record 3 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-05 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-05-3
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-06·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-06·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-06 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-06 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-06-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-06·2
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-06·2
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-06 (record 2 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-06 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-06-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-07·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-07·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-07 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-07 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-07-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-08·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-08·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-08 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-08 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-08-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-08·2
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-08·2
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-08 (record 2 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-08 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-08-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-08·3
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-08·3
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-08 (record 3 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-08 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-08-3
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-08·4
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-08·4
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-08 (record 4 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-08 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-08-4
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-09·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-09·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-09 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-09 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-09-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-09·2
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-09·2
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-09 (record 2 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-09 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-09-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-09·3
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-09·3
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-09 (record 3 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-09 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-09-3
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-09·4
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-09·4
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-09 (record 4 of that day)
Requested:   https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (no answering URL was recorded for this observation)
Response:    NO RESPONSE ARRIVED, fetched blocked, URLError
             The collector records a status of 0 and 0 bytes when no response
             arrived; neither is a measurement, and neither is published as
             one.
Digest:      NONE RECORDED. No response arrived, and no normalised text was
             retained for this observation, so nothing was hashed. This
             citation asserts no digest.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-09 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-09-4
Full record: https://gxplex.com/api/v1/series.jsonl
 no response arrived · URLError blocked — no response arrived on this occasion, so nothing was hashed
2026-08-09·5
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-09·5
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-09 (record 5 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-09 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-09-5
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-09·6
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-09·6
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-09 (record 6 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-09 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-09-6
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-09·7
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-09·7
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-09 (record 7 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-09 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-09-7
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-09·8
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-09·8
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-09 (record 8 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-09 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-09-8
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-10·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-10·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-10 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-10 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-10-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-10·2
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-10·2
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-10 (record 2 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-10 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-10-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-10·3
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-10·3
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-10 (record 3 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-10 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-10-3
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-10·4
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-10·4
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-10 (record 4 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-10 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-10-4
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-10·5
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-10·5
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-10 (record 5 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-10 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-10-5
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-10·6
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-10·6
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-10 (record 6 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-11 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-10-6
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-11·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-11·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-11 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-11 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-11-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-11·2
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-11·2
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-11 (record 2 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-12 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-11-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-11·3
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-11·3
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-11 (record 3 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-12 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-11-3
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-12·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-12·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-12 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-12 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-12-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-12·2
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-12·2
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-12 (record 2 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-12 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-12-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-12·3
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-12·3
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-12 (record 3 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-12 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-12-3
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-12·4
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-12·4
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-12 (record 4 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-12 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-12-4
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-12·5
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-12·5
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-12 (record 5 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-12 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-12-5
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-12·6
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-12·6
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-12 (record 6 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-12 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-12-6
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-12·7
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-12·7
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-12 (record 7 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-12 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-12-7
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-12·8
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-12·8
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-12 (record 8 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-12 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-12-8
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-12·9
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-12·9
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-12 (record 9 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-12 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-12-9
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-13·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-13·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-13 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-13 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-13-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-14·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-14·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-14 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-14 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-14-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-15·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-15·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-15 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-15 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-15-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-15·2
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-15·2
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-15 (record 2 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-15 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-15-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-15·3
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-15·3
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-15 (record 3 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-15 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-15-3
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-16·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-16·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-16 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-16 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-16-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-16·2
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-16·2
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-16 (record 2 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-16 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-16-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-16·3
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-16·3
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-16 (record 3 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-16 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-16-3
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-16·4
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-16·4
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-16 (record 4 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-16 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-16-4
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-17·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-17·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-17 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-17 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-17-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-18·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-18·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-18 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-18 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-18-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-19·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-19·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-19 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-19 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-19-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-20·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-20·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-20 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-20 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-20-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-21·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-21·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-21 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-21 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-21-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-22·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-22·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-22 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-22 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-22-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-22·2
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-22·2
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-22 (record 2 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-22 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-22-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-23·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-23·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-23 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-23 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-23-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-24·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-24·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-24 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-24 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-24-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-25·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-25·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-25 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-25 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-25-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-25·2
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-25·2
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-25 (record 2 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-25 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-25-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-26·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-26·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-26 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-26 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-26-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-26·2
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-26·2
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-26 (record 2 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-26 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-26-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-27·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-27·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-27 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-27 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-27-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-28·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-28·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-28 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-28 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-28-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-29·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-29·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-29 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-29 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-29-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-29·2
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-29·2
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-29 (record 2 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-29 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-29-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-30·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-30·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-30 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-30 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-30-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-30·2
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-30·2
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-30 (record 2 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-30 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-30-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-08-31·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-08-31·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-08-31 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-08-31 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-08-31-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-09-01·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-09-01·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-09-01 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-09-01 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-09-01-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-09-02·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-09-02·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-09-02 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260731203942/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-07-31, before this observation
             was recorded on 2026-09-02 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-09-02-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-09-02·2
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-09-02·2
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-09-02 (record 2 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260902233914/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-09-02 — the day this
             observation was recorded, UTC.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-09-02-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-09-03·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-09-03·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-09-03 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260902233914/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-09-02, before this observation
             was recorded on 2026-09-03 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-09-03-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-09-04·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-09-04·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-09-04 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260902233914/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-09-02, before this observation
             was recorded on 2026-09-04 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-09-04-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-09-04·2
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-09-04·2
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-09-04 (record 2 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260902233914/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-09-02, before this observation
             was recorded on 2026-09-04 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-09-04-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-09-05·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-09-05·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-09-05 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260902233914/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-09-02, before this observation
             was recorded on 2026-09-05 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-09-05-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-09-05·2
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-09-05·2
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-09-05 (record 2 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260902233914/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-09-02, before this observation
             was recorded on 2026-09-05 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-09-05-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-09-05·3
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-09-05·3
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-09-05 (record 3 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260902233914/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-09-02, before this observation
             was recorded on 2026-09-05 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-09-05-3
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-09-05·4
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-09-05·4
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-09-05 (record 4 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260902233914/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-09-02, before this observation
             was recorded on 2026-09-05 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-09-05-4
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-09-05·5
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-09-05·5
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-09-05 (record 5 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260902233914/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-09-02, before this observation
             was recorded on 2026-09-05 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-09-05-5
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-09-05·6
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-09-05·6
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-09-05 (record 6 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260902233914/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-09-02, before this observation
             was recorded on 2026-09-05 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-09-05-6
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-09-05·7
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-09-05·7
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-09-05 (record 7 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260902233914/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-09-02, before this observation
             was recorded on 2026-09-05 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-09-05-7
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-09-05·8
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-09-05·8
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-09-05 (record 8 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260902233914/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-09-02, before this observation
             was recorded on 2026-09-05 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-09-05-8
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-09-05·9
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-09-05·9
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-09-05 (record 9 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260902233914/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-09-02, before this observation
             was recorded on 2026-09-05 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-09-05-9
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-09-06·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-09-06·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-09-06 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260902233914/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-09-02, before this observation
             was recorded on 2026-09-06 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-09-06-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-09-07·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-09-07·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-09-07 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
             45,822 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260902233914/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-09-02, before this observation
             was recorded on 2026-09-07 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-09-07-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 45,822 chars 08b4462d76fa54f222e36450aa8b651e1751c22bfb56f3d06677c5d103afbbe7
2026-09-08·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-09-08·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-09-08 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 acd195a087c3a38e76efac69faf4e1d605e7103865d81147dabca89ec69f57c1
             11,250 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260902233914/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-09-02, before this observation
             was recorded on 2026-09-08 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-09-08-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 11,250 chars acd195a087c3a38e76efac69faf4e1d605e7103865d81147dabca89ec69f57c1
2026-09-09·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-09-09·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-09-09 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 acd195a087c3a38e76efac69faf4e1d605e7103865d81147dabca89ec69f57c1
             11,250 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260902233914/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-09-02, before this observation
             was recorded on 2026-09-09 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-09-09-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 11,250 chars acd195a087c3a38e76efac69faf4e1d605e7103865d81147dabca89ec69f57c1
2026-09-10·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-09-10·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-09-10 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 acd195a087c3a38e76efac69faf4e1d605e7103865d81147dabca89ec69f57c1
             11,250 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260902233914/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-09-02, before this observation
             was recorded on 2026-09-10 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-09-10-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 11,250 chars acd195a087c3a38e76efac69faf4e1d605e7103865d81147dabca89ec69f57c1
2026-09-11·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-09-11·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-09-11 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 acd195a087c3a38e76efac69faf4e1d605e7103865d81147dabca89ec69f57c1
             11,250 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260902233914/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-09-02, before this observation
             was recorded on 2026-09-11 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-09-11-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 11,250 chars acd195a087c3a38e76efac69faf4e1d605e7103865d81147dabca89ec69f57c1
2026-09-12·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-09-12·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-09-12 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 acd195a087c3a38e76efac69faf4e1d605e7103865d81147dabca89ec69f57c1
             11,250 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260902233914/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-09-02, before this observation
             was recorded on 2026-09-12 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-09-12-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 11,250 chars acd195a087c3a38e76efac69faf4e1d605e7103865d81147dabca89ec69f57c1
2026-09-13·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-09-13·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-09-13 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 acd195a087c3a38e76efac69faf4e1d605e7103865d81147dabca89ec69f57c1
             11,250 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260902233914/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-09-02, before this observation
             was recorded on 2026-09-13 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-09-13-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 11,250 chars acd195a087c3a38e76efac69faf4e1d605e7103865d81147dabca89ec69f57c1
2026-09-14·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-09-14·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-09-14 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 acd195a087c3a38e76efac69faf4e1d605e7103865d81147dabca89ec69f57c1
             11,250 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260902233914/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-09-02, before this observation
             was recorded on 2026-09-14 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-09-14-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 11,250 chars acd195a087c3a38e76efac69faf4e1d605e7103865d81147dabca89ec69f57c1
2026-09-15·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-09-15·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-09-15 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 acd195a087c3a38e76efac69faf4e1d605e7103865d81147dabca89ec69f57c1
             11,250 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260902233914/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-09-02, before this observation
             was recorded on 2026-09-15 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-09-15-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 11,250 chars acd195a087c3a38e76efac69faf4e1d605e7103865d81147dabca89ec69f57c1
2026-09-16·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-09-16·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-09-16 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 acd195a087c3a38e76efac69faf4e1d605e7103865d81147dabca89ec69f57c1
             11,250 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260902233914/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-09-02, before this observation
             was recorded on 2026-09-16 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-09-16-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 11,250 chars acd195a087c3a38e76efac69faf4e1d605e7103865d81147dabca89ec69f57c1
2026-09-17·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-09-17·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-09-17 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 acd195a087c3a38e76efac69faf4e1d605e7103865d81147dabca89ec69f57c1
             11,250 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260902233914/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-09-02, before this observation
             was recorded on 2026-09-17 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-09-17-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 11,250 chars acd195a087c3a38e76efac69faf4e1d605e7103865d81147dabca89ec69f57c1
2026-09-18·1
Cite this observation 
GxPlex observation record ema-pics-annex15-concept 2026-09-18·1
Document:    EMA and PIC/S concept paper on the revision of GMP Annex 15
Observed:    2026-09-18 (record 1 of that day)
Answered at: https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
Response:    HTTP 200, fetched direct, 167,796 bytes returned
Digest:      SHA-256 acd195a087c3a38e76efac69faf4e1d605e7103865d81147dabca89ec69f57c1
             11,250 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260902233914/https://www.ema.europa.eu/en/documents/scientific-guideline/concept-paper-revision-guidelines-good-manufacturing-practice-medicinal-products-annex-15-qualification-validation-corrigendum_en.pdf
             (Internet Archive, submitted 2026-09-02, before this observation
             was recorded on 2026-09-18 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/ema-pics-annex15-concept#obs-2026-09-18-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 167,796 bytes returned direct 11,250 chars acd195a087c3a38e76efac69faf4e1d605e7103865d81147dabca89ec69f57c1

Every record above is published untruncated at /api/v1/series.jsonl, which carries the same sequence these addresses are built from.