GxPlex

Observation series — EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014

← EU GMP Annex 13

54 observation(s) recorded. 54 carry an address; none is without one. 54 retained normalised text and hold a digest.

Each observation is addressed by this row’s identifier, the date it was observed, and its sequence within that date — the same key /api/v1/series.jsonl publishes as `sequence`, counted in the order the store recorded them.

This digest is a leaf of the integrity root, and the command that recomputes it is published at /verify.

Every addressed record below carries its own citation, naming the day, the URL that answered, the response as recorded, and the digest where one exists. Where none exists the citation says so and asserts no digest.

Address Date Outcome Method Normalised text SHA-256 of normalised text
2026-08-15·1
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-08-15·1
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-08-15 (record 1 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-08-15-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-08-15·2
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-08-15·2
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-08-15 (record 2 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15 — the day this
             observation was recorded, UTC.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-08-15-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-08-16·1
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-08-16·1
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-08-16 (record 1 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-08-16 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-08-16-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-08-16·2
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-08-16·2
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-08-16 (record 2 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-08-16 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-08-16-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-08-16·3
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-08-16·3
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-08-16 (record 3 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-08-16 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-08-16-3
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-08-16·4
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-08-16·4
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-08-16 (record 4 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-08-16 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-08-16-4
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-08-17·1
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-08-17·1
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-08-17 (record 1 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-08-17 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-08-17-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-08-18·1
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-08-18·1
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-08-18 (record 1 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-08-18 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-08-18-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-08-19·1
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-08-19·1
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-08-19 (record 1 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-08-19 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-08-19-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-08-20·1
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-08-20·1
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-08-20 (record 1 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-08-20 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-08-20-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-08-21·1
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-08-21·1
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-08-21 (record 1 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-08-21 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-08-21-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-08-22·1
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-08-22·1
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-08-22 (record 1 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-08-22 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-08-22-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-08-22·2
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-08-22·2
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-08-22 (record 2 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-08-22 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-08-22-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-08-23·1
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-08-23·1
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-08-23 (record 1 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-08-23 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-08-23-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-08-24·1
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-08-24·1
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-08-24 (record 1 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-08-24 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-08-24-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-08-25·1
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-08-25·1
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-08-25 (record 1 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-08-25 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-08-25-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-08-25·2
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-08-25·2
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-08-25 (record 2 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-08-25 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-08-25-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-08-26·1
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-08-26·1
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-08-26 (record 1 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-08-26 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-08-26-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-08-26·2
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-08-26·2
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-08-26 (record 2 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-08-26 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-08-26-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-08-27·1
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-08-27·1
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-08-27 (record 1 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-08-27 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-08-27-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-08-28·1
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-08-28·1
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-08-28 (record 1 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-08-28 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-08-28-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-08-29·1
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-08-29·1
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-08-29 (record 1 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-08-29 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-08-29-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-08-29·2
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-08-29·2
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-08-29 (record 2 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-08-29 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-08-29-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-08-30·1
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-08-30·1
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-08-30 (record 1 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-08-30 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-08-30-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-08-30·2
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-08-30·2
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-08-30 (record 2 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-08-30 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-08-30-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-08-31·1
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-08-31·1
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-08-31 (record 1 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-08-31 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-08-31-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-09-01·1
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-09-01·1
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-09-01 (record 1 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-09-01 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-09-01-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-09-02·1
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-09-02·1
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-09-02 (record 1 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-09-02 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-09-02-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-09-02·2
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-09-02·2
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-09-02 (record 2 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-09-02 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-09-02-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-09-03·1
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-09-03·1
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-09-03 (record 1 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-09-03 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-09-03-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-09-04·1
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-09-04·1
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-09-04 (record 1 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-09-04 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-09-04-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-09-04·2
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-09-04·2
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-09-04 (record 2 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-09-04 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-09-04-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-09-05·1
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-09-05·1
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-09-05 (record 1 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-09-05 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-09-05-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-09-05·2
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-09-05·2
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-09-05 (record 2 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-09-05 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-09-05-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-09-05·3
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-09-05·3
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-09-05 (record 3 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-09-05 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-09-05-3
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-09-05·4
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-09-05·4
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-09-05 (record 4 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-09-05 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-09-05-4
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-09-05·5
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-09-05·5
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-09-05 (record 5 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-09-05 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-09-05-5
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-09-05·6
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-09-05·6
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-09-05 (record 6 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-09-05 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-09-05-6
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-09-05·7
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-09-05·7
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-09-05 (record 7 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-09-05 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-09-05-7
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-09-05·8
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-09-05·8
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-09-05 (record 8 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-09-05 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-09-05-8
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-09-05·9
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-09-05·9
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-09-05 (record 9 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-09-05 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-09-05-9
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-09-06·1
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-09-06·1
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-09-06 (record 1 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-09-06 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-09-06-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-09-07·1
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-09-07·1
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-09-07 (record 1 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
             51,473 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-09-07 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-09-07-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 51,473 chars 48f21f2e4f1b1fbde381de7941e8c1d974b78038ccd6d14cdff59d498bda8157
2026-09-08·1
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-09-08·1
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-09-08 (record 1 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 c4635c9c95ba5033d5f3ea4494a29f111aab85ade5ed5dd938f1cd3b0e964daa
             44,122 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-09-08 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-09-08-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 44,122 chars c4635c9c95ba5033d5f3ea4494a29f111aab85ade5ed5dd938f1cd3b0e964daa
2026-09-09·1
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-09-09·1
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-09-09 (record 1 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 c4635c9c95ba5033d5f3ea4494a29f111aab85ade5ed5dd938f1cd3b0e964daa
             44,122 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-09-09 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-09-09-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 44,122 chars c4635c9c95ba5033d5f3ea4494a29f111aab85ade5ed5dd938f1cd3b0e964daa
2026-09-10·1
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-09-10·1
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-09-10 (record 1 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 c4635c9c95ba5033d5f3ea4494a29f111aab85ade5ed5dd938f1cd3b0e964daa
             44,122 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-09-10 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-09-10-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 44,122 chars c4635c9c95ba5033d5f3ea4494a29f111aab85ade5ed5dd938f1cd3b0e964daa
2026-09-11·1
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-09-11·1
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-09-11 (record 1 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 c4635c9c95ba5033d5f3ea4494a29f111aab85ade5ed5dd938f1cd3b0e964daa
             44,122 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-09-11 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-09-11-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 44,122 chars c4635c9c95ba5033d5f3ea4494a29f111aab85ade5ed5dd938f1cd3b0e964daa
2026-09-12·1
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-09-12·1
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-09-12 (record 1 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 c4635c9c95ba5033d5f3ea4494a29f111aab85ade5ed5dd938f1cd3b0e964daa
             44,122 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-09-12 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-09-12-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 44,122 chars c4635c9c95ba5033d5f3ea4494a29f111aab85ade5ed5dd938f1cd3b0e964daa
2026-09-13·1
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-09-13·1
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-09-13 (record 1 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 c4635c9c95ba5033d5f3ea4494a29f111aab85ade5ed5dd938f1cd3b0e964daa
             44,122 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-09-13 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-09-13-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 44,122 chars c4635c9c95ba5033d5f3ea4494a29f111aab85ade5ed5dd938f1cd3b0e964daa
2026-09-14·1
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-09-14·1
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-09-14 (record 1 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 c4635c9c95ba5033d5f3ea4494a29f111aab85ade5ed5dd938f1cd3b0e964daa
             44,122 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-09-14 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-09-14-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 44,122 chars c4635c9c95ba5033d5f3ea4494a29f111aab85ade5ed5dd938f1cd3b0e964daa
2026-09-15·1
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-09-15·1
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-09-15 (record 1 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 c4635c9c95ba5033d5f3ea4494a29f111aab85ade5ed5dd938f1cd3b0e964daa
             44,122 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-09-15 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-09-15-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 44,122 chars c4635c9c95ba5033d5f3ea4494a29f111aab85ade5ed5dd938f1cd3b0e964daa
2026-09-16·1
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-09-16·1
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-09-16 (record 1 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 c4635c9c95ba5033d5f3ea4494a29f111aab85ade5ed5dd938f1cd3b0e964daa
             44,122 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-09-16 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-09-16-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 44,122 chars c4635c9c95ba5033d5f3ea4494a29f111aab85ade5ed5dd938f1cd3b0e964daa
2026-09-17·1
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-09-17·1
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-09-17 (record 1 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 c4635c9c95ba5033d5f3ea4494a29f111aab85ade5ed5dd938f1cd3b0e964daa
             44,122 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-09-17 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-09-17-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 44,122 chars c4635c9c95ba5033d5f3ea4494a29f111aab85ade5ed5dd938f1cd3b0e964daa
2026-09-18·1
Cite this observation 
GxPlex observation record eu-gmp-annex-13 2026-09-18·1
Document:    EudraLex Volume 4, Annex 13 — Detailed Commission guideline of 8 December 2017 on the good manufacturing practice for investigational medicinal products pursuant to the second paragraph of the Article 63(1) of Regulation (EU) No 536/2014
Observed:    2026-09-18 (record 1 of that day)
Answered at: https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
Response:    HTTP 200, fetched direct, 182,328 bytes returned
Digest:      SHA-256 c4635c9c95ba5033d5f3ea4494a29f111aab85ade5ed5dd938f1cd3b0e964daa
             44,122 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260815200703/https://health.ec.europa.eu/document/download/a0b206a0-5788-406b-9e20-e0525b16e712_en?filename=guideline_adopted_1_en_act_part1_v3.pdf
             (Internet Archive, submitted 2026-08-15, before this observation
             was recorded on 2026-09-18 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/eu-gmp-annex-13#obs-2026-09-18-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 182,328 bytes returned direct 44,122 chars c4635c9c95ba5033d5f3ea4494a29f111aab85ade5ed5dd938f1cd3b0e964daa

Every record above is published untruncated at /api/v1/series.jsonl, which carries the same sequence these addresses are built from.