GxPlex

Observation series — General Principles of Software Validation

← FDA software validation

110 observation(s) recorded. 110 carry an address; none is without one. 110 retained normalised text and hold a digest.

Each observation is addressed by this row’s identifier, the date it was observed, and its sequence within that date — the same key /api/v1/series.jsonl publishes as `sequence`, counted in the order the store recorded them.

This digest is a leaf of the integrity root, and the command that recomputes it is published at /verify.

Every addressed record below carries its own citation, naming the day, the URL that answered, the response as recorded, and the digest where one exists. Where none exists the citation says so and asserts no digest.

Address Date Outcome Method Normalised text SHA-256 of normalised text
2026-07-31·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-07-31·1
Document:    General Principles of Software Validation
Observed:    2026-07-31 (record 1 of that day)
Requested:   https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (no answering URL was recorded for this observation)
Response:    HTTP 200, fetched direct, 35,436 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-07-31-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,436 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-07-31·2
Cite this observation 
GxPlex observation record fda-software-validation 2026-07-31·2
Document:    General Principles of Software Validation
Observed:    2026-07-31 (record 2 of that day)
Requested:   https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (no answering URL was recorded for this observation)
Response:    HTTP 200, fetched direct, 35,436 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-07-31-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,436 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-07-31·3
Cite this observation 
GxPlex observation record fda-software-validation 2026-07-31·3
Document:    General Principles of Software Validation
Observed:    2026-07-31 (record 3 of that day)
Requested:   https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (no answering URL was recorded for this observation)
Response:    HTTP 200, fetched direct, 35,436 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-07-31-3
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,436 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-07-31·4
Cite this observation 
GxPlex observation record fda-software-validation 2026-07-31·4
Document:    General Principles of Software Validation
Observed:    2026-07-31 (record 4 of that day)
Requested:   https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (no answering URL was recorded for this observation)
Response:    HTTP 200, fetched direct, 35,436 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-07-31-4
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,436 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-07-31·5
Cite this observation 
GxPlex observation record fda-software-validation 2026-07-31·5
Document:    General Principles of Software Validation
Observed:    2026-07-31 (record 5 of that day)
Requested:   https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (no answering URL was recorded for this observation)
Response:    HTTP 200, fetched direct, 35,473 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-07-31-5
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,473 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-07-31·6
Cite this observation 
GxPlex observation record fda-software-validation 2026-07-31·6
Document:    General Principles of Software Validation
Observed:    2026-07-31 (record 6 of that day)
Requested:   https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (no answering URL was recorded for this observation)
Response:    HTTP 200, fetched direct, 35,473 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-07-31-6
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,473 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-01·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-01·1
Document:    General Principles of Software Validation
Observed:    2026-08-01 (record 1 of that day)
Requested:   https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (no answering URL was recorded for this observation)
Response:    HTTP 200, fetched direct, 35,443 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-01-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,443 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-01·2
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-01·2
Document:    General Principles of Software Validation
Observed:    2026-08-01 (record 2 of that day)
Requested:   https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (no answering URL was recorded for this observation)
Response:    HTTP 200, fetched direct, 35,443 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-01-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,443 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-01·3
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-01·3
Document:    General Principles of Software Validation
Observed:    2026-08-01 (record 3 of that day)
Requested:   https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (no answering URL was recorded for this observation)
Response:    HTTP 200, fetched direct, 35,438 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02 — the day this
             observation was recorded, UTC. The day named above, 2026-08-01,
             is this record's local day; the two clocks differ for this
             record.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-01-3
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,438 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-02·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-02·1
Document:    General Principles of Software Validation
Observed:    2026-08-02 (record 1 of that day)
Requested:   https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (no answering URL was recorded for this observation)
Response:    HTTP 200, fetched direct, 35,438 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02 — the day this
             observation was recorded, UTC.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-02-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,438 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-02·2
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-02·2
Document:    General Principles of Software Validation
Observed:    2026-08-02 (record 2 of that day)
Requested:   https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (no answering URL was recorded for this observation)
Response:    HTTP 200, fetched direct, 35,438 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02 — the day this
             observation was recorded, UTC.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-02-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,438 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-02·3
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-02·3
Document:    General Principles of Software Validation
Observed:    2026-08-02 (record 3 of that day)
Requested:   https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (no answering URL was recorded for this observation)
Response:    HTTP 200, fetched direct, 35,438 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02 — the day this
             observation was recorded, UTC.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-02-3
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,438 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-03·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-03·1
Document:    General Principles of Software Validation
Observed:    2026-08-03 (record 1 of that day)
Requested:   https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (no answering URL was recorded for this observation)
Response:    HTTP 200, fetched direct, 35,438 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-03 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-03-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,438 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-03·2
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-03·2
Document:    General Principles of Software Validation
Observed:    2026-08-03 (record 2 of that day)
Requested:   https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (no answering URL was recorded for this observation)
Response:    HTTP 200, fetched direct, 35,438 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-03 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-03-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,438 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-03·3
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-03·3
Document:    General Principles of Software Validation
Observed:    2026-08-03 (record 3 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,475 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-03 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-03-3
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,475 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-04·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-04·1
Document:    General Principles of Software Validation
Observed:    2026-08-04 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,474 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-04 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-04-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,474 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-04·2
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-04·2
Document:    General Principles of Software Validation
Observed:    2026-08-04 (record 2 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,437 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-04 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-04-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,437 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-05·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-05·1
Document:    General Principles of Software Validation
Observed:    2026-08-05 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,435 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-05 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-05-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,435 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-05·2
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-05·2
Document:    General Principles of Software Validation
Observed:    2026-08-05 (record 2 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,435 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-05 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-05-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,435 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-05·3
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-05·3
Document:    General Principles of Software Validation
Observed:    2026-08-05 (record 3 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,435 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-05 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-05-3
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,435 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-06·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-06·1
Document:    General Principles of Software Validation
Observed:    2026-08-06 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,433 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-06 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-06-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,433 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-06·2
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-06·2
Document:    General Principles of Software Validation
Observed:    2026-08-06 (record 2 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,433 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-06 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-06-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,433 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-07·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-07·1
Document:    General Principles of Software Validation
Observed:    2026-08-07 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,441 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-07 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-07-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,441 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-08·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-08·1
Document:    General Principles of Software Validation
Observed:    2026-08-08 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,471 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-08 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-08-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,471 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-08·2
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-08·2
Document:    General Principles of Software Validation
Observed:    2026-08-08 (record 2 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,434 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-08 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-08-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,434 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-08·3
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-08·3
Document:    General Principles of Software Validation
Observed:    2026-08-08 (record 3 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,434 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-08 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-08-3
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,434 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-08·4
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-08·4
Document:    General Principles of Software Validation
Observed:    2026-08-08 (record 4 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,434 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-08 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-08-4
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,434 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-09·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-09·1
Document:    General Principles of Software Validation
Observed:    2026-08-09 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,434 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-09 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-09-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,434 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-09·2
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-09·2
Document:    General Principles of Software Validation
Observed:    2026-08-09 (record 2 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,434 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-09 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-09-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,434 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-09·3
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-09·3
Document:    General Principles of Software Validation
Observed:    2026-08-09 (record 3 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,434 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-09 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-09-3
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,434 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-09·4
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-09·4
Document:    General Principles of Software Validation
Observed:    2026-08-09 (record 4 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,434 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-09 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-09-4
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,434 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-09·5
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-09·5
Document:    General Principles of Software Validation
Observed:    2026-08-09 (record 5 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,434 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-09 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-09-5
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,434 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-09·6
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-09·6
Document:    General Principles of Software Validation
Observed:    2026-08-09 (record 6 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,434 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-09 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-09-6
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,434 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-09·7
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-09·7
Document:    General Principles of Software Validation
Observed:    2026-08-09 (record 7 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,434 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-09 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-09-7
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,434 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-09·8
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-09·8
Document:    General Principles of Software Validation
Observed:    2026-08-09 (record 8 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,434 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-09 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-09-8
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,434 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-10·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-10·1
Document:    General Principles of Software Validation
Observed:    2026-08-10 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,470 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-10 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-10-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,470 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-10·2
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-10·2
Document:    General Principles of Software Validation
Observed:    2026-08-10 (record 2 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,470 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-10 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-10-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,470 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-10·3
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-10·3
Document:    General Principles of Software Validation
Observed:    2026-08-10 (record 3 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,470 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-10 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-10-3
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,470 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-10·4
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-10·4
Document:    General Principles of Software Validation
Observed:    2026-08-10 (record 4 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,433 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-10 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-10-4
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,433 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-10·5
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-10·5
Document:    General Principles of Software Validation
Observed:    2026-08-10 (record 5 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,433 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-10 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-10-5
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,433 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-10·6
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-10·6
Document:    General Principles of Software Validation
Observed:    2026-08-10 (record 6 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,445 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-11 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-10-6
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,445 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-11·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-11·1
Document:    General Principles of Software Validation
Observed:    2026-08-11 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,445 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-11 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-11-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,445 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-11·2
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-11·2
Document:    General Principles of Software Validation
Observed:    2026-08-11 (record 2 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,428 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-12 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-11-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,428 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-11·3
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-11·3
Document:    General Principles of Software Validation
Observed:    2026-08-11 (record 3 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,428 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-12 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-11-3
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,428 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-12·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-12·1
Document:    General Principles of Software Validation
Observed:    2026-08-12 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,428 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-12 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-12-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,428 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-12·2
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-12·2
Document:    General Principles of Software Validation
Observed:    2026-08-12 (record 2 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,428 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-12 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-12-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,428 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-12·3
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-12·3
Document:    General Principles of Software Validation
Observed:    2026-08-12 (record 3 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,428 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-12 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-12-3
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,428 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-12·4
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-12·4
Document:    General Principles of Software Validation
Observed:    2026-08-12 (record 4 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,428 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-12 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-12-4
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,428 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-12·5
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-12·5
Document:    General Principles of Software Validation
Observed:    2026-08-12 (record 5 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,428 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-12 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-12-5
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,428 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-12·6
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-12·6
Document:    General Principles of Software Validation
Observed:    2026-08-12 (record 6 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,428 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-12 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-12-6
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,428 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-12·7
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-12·7
Document:    General Principles of Software Validation
Observed:    2026-08-12 (record 7 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,428 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-12 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-12-7
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,428 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-12·8
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-12·8
Document:    General Principles of Software Validation
Observed:    2026-08-12 (record 8 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,428 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-12 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-12-8
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,428 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-12·9
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-12·9
Document:    General Principles of Software Validation
Observed:    2026-08-12 (record 9 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,428 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-12 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-12-9
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,428 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-13·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-13·1
Document:    General Principles of Software Validation
Observed:    2026-08-13 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,439 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-13 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-13-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,439 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-14·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-14·1
Document:    General Principles of Software Validation
Observed:    2026-08-14 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,432 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-14 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-14-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,432 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-15·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-15·1
Document:    General Principles of Software Validation
Observed:    2026-08-15 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,441 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-15 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-15-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,441 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-15·2
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-15·2
Document:    General Principles of Software Validation
Observed:    2026-08-15 (record 2 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,441 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-15 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-15-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,441 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-15·3
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-15·3
Document:    General Principles of Software Validation
Observed:    2026-08-15 (record 3 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,441 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-15 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-15-3
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,441 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-16·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-16·1
Document:    General Principles of Software Validation
Observed:    2026-08-16 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,435 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-16 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-16-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,435 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-16·2
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-16·2
Document:    General Principles of Software Validation
Observed:    2026-08-16 (record 2 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,435 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-16 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-16-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,435 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-16·3
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-16·3
Document:    General Principles of Software Validation
Observed:    2026-08-16 (record 3 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,435 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-16 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-16-3
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,435 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-16·4
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-16·4
Document:    General Principles of Software Validation
Observed:    2026-08-16 (record 4 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,435 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-16 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-16-4
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,435 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-17·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-17·1
Document:    General Principles of Software Validation
Observed:    2026-08-17 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,438 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-17 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-17-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,438 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-18·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-18·1
Document:    General Principles of Software Validation
Observed:    2026-08-18 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,436 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-18 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-18-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,436 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-19·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-19·1
Document:    General Principles of Software Validation
Observed:    2026-08-19 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,481 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-19 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-19-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,481 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-20·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-20·1
Document:    General Principles of Software Validation
Observed:    2026-08-20 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,439 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-20 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-20-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,439 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-21·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-21·1
Document:    General Principles of Software Validation
Observed:    2026-08-21 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,441 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-21 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-21-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,441 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-22·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-22·1
Document:    General Principles of Software Validation
Observed:    2026-08-22 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,430 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-22 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-22-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,430 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-22·2
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-22·2
Document:    General Principles of Software Validation
Observed:    2026-08-22 (record 2 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,488 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-22 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-22-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,488 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-23·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-23·1
Document:    General Principles of Software Validation
Observed:    2026-08-23 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,440 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-23 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-23-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,440 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-24·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-24·1
Document:    General Principles of Software Validation
Observed:    2026-08-24 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,435 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-24 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-24-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,435 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-25·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-25·1
Document:    General Principles of Software Validation
Observed:    2026-08-25 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,473 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-25 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-25-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,473 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-25·2
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-25·2
Document:    General Principles of Software Validation
Observed:    2026-08-25 (record 2 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,436 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-25 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-25-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,436 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-26·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-26·1
Document:    General Principles of Software Validation
Observed:    2026-08-26 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,427 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-26 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-26-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,427 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-26·2
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-26·2
Document:    General Principles of Software Validation
Observed:    2026-08-26 (record 2 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,427 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-26 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-26-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,427 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-27·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-27·1
Document:    General Principles of Software Validation
Observed:    2026-08-27 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,439 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-27 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-27-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,439 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-28·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-28·1
Document:    General Principles of Software Validation
Observed:    2026-08-28 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,439 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-28 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-28-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,439 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-29·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-29·1
Document:    General Principles of Software Validation
Observed:    2026-08-29 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,434 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-29 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-29-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,434 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-29·2
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-29·2
Document:    General Principles of Software Validation
Observed:    2026-08-29 (record 2 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,434 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-29 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-29-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,434 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-30·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-30·1
Document:    General Principles of Software Validation
Observed:    2026-08-30 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,429 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-30 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-30-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,429 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-30·2
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-30·2
Document:    General Principles of Software Validation
Observed:    2026-08-30 (record 2 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,429 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-30 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-30-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,429 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-08-31·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-08-31·1
Document:    General Principles of Software Validation
Observed:    2026-08-31 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,444 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-08-31 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-08-31-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,444 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-09-01·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-09-01·1
Document:    General Principles of Software Validation
Observed:    2026-09-01 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,434 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-09-01 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-09-01-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,434 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-09-02·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-09-02·1
Document:    General Principles of Software Validation
Observed:    2026-09-02 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,434 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-09-02 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-09-02-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,434 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-09-02·2
Cite this observation 
GxPlex observation record fda-software-validation 2026-09-02·2
Document:    General Principles of Software Validation
Observed:    2026-09-02 (record 2 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 34,929 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-09-02 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-09-02-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 34,929 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-09-03·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-09-03·1
Document:    General Principles of Software Validation
Observed:    2026-09-03 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 34,919 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-09-03 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-09-03-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 34,919 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-09-04·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-09-04·1
Document:    General Principles of Software Validation
Observed:    2026-09-04 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 34,933 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-09-04 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-09-04-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 34,933 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-09-04·2
Cite this observation 
GxPlex observation record fda-software-validation 2026-09-04·2
Document:    General Principles of Software Validation
Observed:    2026-09-04 (record 2 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 34,970 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-09-04 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-09-04-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 34,970 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-09-05·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-09-05·1
Document:    General Principles of Software Validation
Observed:    2026-09-05 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 34,924 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-09-05 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-09-05-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 34,924 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-09-05·2
Cite this observation 
GxPlex observation record fda-software-validation 2026-09-05·2
Document:    General Principles of Software Validation
Observed:    2026-09-05 (record 2 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 34,924 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-09-05 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-09-05-2
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 34,924 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-09-05·3
Cite this observation 
GxPlex observation record fda-software-validation 2026-09-05·3
Document:    General Principles of Software Validation
Observed:    2026-09-05 (record 3 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 34,924 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-09-05 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-09-05-3
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 34,924 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-09-05·4
Cite this observation 
GxPlex observation record fda-software-validation 2026-09-05·4
Document:    General Principles of Software Validation
Observed:    2026-09-05 (record 4 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 34,924 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-09-05 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-09-05-4
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 34,924 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-09-05·5
Cite this observation 
GxPlex observation record fda-software-validation 2026-09-05·5
Document:    General Principles of Software Validation
Observed:    2026-09-05 (record 5 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 34,924 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-09-05 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-09-05-5
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 34,924 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-09-05·6
Cite this observation 
GxPlex observation record fda-software-validation 2026-09-05·6
Document:    General Principles of Software Validation
Observed:    2026-09-05 (record 6 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 34,924 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-09-05 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-09-05-6
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 34,924 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-09-05·7
Cite this observation 
GxPlex observation record fda-software-validation 2026-09-05·7
Document:    General Principles of Software Validation
Observed:    2026-09-05 (record 7 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 34,924 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-09-05 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-09-05-7
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 34,924 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-09-05·8
Cite this observation 
GxPlex observation record fda-software-validation 2026-09-05·8
Document:    General Principles of Software Validation
Observed:    2026-09-05 (record 8 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 34,924 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-09-05 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-09-05-8
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 34,924 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-09-05·9
Cite this observation 
GxPlex observation record fda-software-validation 2026-09-05·9
Document:    General Principles of Software Validation
Observed:    2026-09-05 (record 9 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 34,924 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-09-05 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-09-05-9
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 34,924 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-09-06·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-09-06·1
Document:    General Principles of Software Validation
Observed:    2026-09-06 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 34,929 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-09-06 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-09-06-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 34,929 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-09-07·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-09-07·1
Document:    General Principles of Software Validation
Observed:    2026-09-07 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 34,920 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-09-07 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-09-07-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 34,920 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-09-08·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-09-08·1
Document:    General Principles of Software Validation
Observed:    2026-09-08 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 34,929 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-09-08 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-09-08-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 34,929 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-09-09·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-09-09·1
Document:    General Principles of Software Validation
Observed:    2026-09-09 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 34,923 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-09-09 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-09-09-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 34,923 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-09-10·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-09-10·1
Document:    General Principles of Software Validation
Observed:    2026-09-10 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 34,930 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-09-10 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-09-10-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 34,930 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-09-11·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-09-11·1
Document:    General Principles of Software Validation
Observed:    2026-09-11 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 34,960 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-09-11 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-09-11-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 34,960 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-09-12·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-09-12·1
Document:    General Principles of Software Validation
Observed:    2026-09-12 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 34,925 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-09-12 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-09-12-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 34,925 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-09-13·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-09-13·1
Document:    General Principles of Software Validation
Observed:    2026-09-13 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 34,927 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-09-13 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-09-13-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 34,927 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-09-14·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-09-14·1
Document:    General Principles of Software Validation
Observed:    2026-09-14 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 34,926 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-09-14 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-09-14-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 34,926 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-09-15·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-09-15·1
Document:    General Principles of Software Validation
Observed:    2026-09-15 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 34,919 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-09-15 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-09-15-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 34,919 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-09-16·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-09-16·1
Document:    General Principles of Software Validation
Observed:    2026-09-16 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,090 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-09-16 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-09-16-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,090 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-09-17·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-09-17·1
Document:    General Principles of Software Validation
Observed:    2026-09-17 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,079 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-09-17 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-09-17-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,079 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
2026-09-18·1
Cite this observation 
GxPlex observation record fda-software-validation 2026-09-18·1
Document:    General Principles of Software Validation
Observed:    2026-09-18 (record 1 of that day)
Answered at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
Response:    HTTP 200, fetched direct, 35,086 bytes returned
Digest:      SHA-256 c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea
             1,268 characters of normalised text.
             The digest is of the NORMALISED text, not of the bytes served:
             tags, scripts, navigation and volatile strings are removed before
             hashing, so hashing the source as served will not reproduce it.
             Normalisation is described at https://gxplex.com/methodology; the
             command that recomputes a digest is published at
             https://gxplex.com/verify.
Capture:     https://web.archive.org/web/20260802003230/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/general-principles-software-validation
             (Internet Archive, submitted 2026-08-02, before this observation
             was recorded on 2026-09-18 UTC. NOT a capture of this
             observation.)
Permalink:   https://gxplex.com/observations/fda-software-validation#obs-2026-09-18-1
Full record: https://gxplex.com/api/v1/series.jsonl
 HTTP 200 · 35,086 bytes returned direct 1,268 chars c49d3a7195156124103da7495e93222a836fcff8c8b92310eca57171bb2677ea

Every record above is published untruncated at /api/v1/series.jsonl, which carries the same sequence these addresses are built from.